Accurate Calculation of Second Osmotic Virial Coefficients of Proteins using Mixed Poisson-Boltzmann and Extended DLVO Theory
نویسندگان
چکیده
New model xDLVO-CGhybr calculating second osmotic virial coefficient of protein solutions is developed. Data calculated agrees well with experiments due to accurate estimation electrostatic protein–protein interactions using a hybrid methodology.
منابع مشابه
Distribution of the second virial coefficients of globular proteins
George and Wilson [Acta. Cryst. D 50, 361 (1994)] looked at the distribution of values of the second virial coefficient of globular proteins, under the conditions at which they crystallise. They found the values to lie within a fairly narrow range. We have defined a simple model of a generic globular protein. We then generate a set of proteins by picking values for the parameters of the model f...
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ژورنال
عنوان ژورنال: Molecular Systems Design and Engineering
سال: 2023
ISSN: ['2058-9689']
DOI: https://doi.org/10.1039/d3me00086a